Apr 1986 Recruit Co., Ltd., joined Jan 1997 Advantage Partners, Inc., joined Mar 1999 Advantage Risk Management Co., Ltd., Director Jun 1999 Chosei Advantage Co., Ltd. (now Advantage Risk Management Co., Ltd.), Representative Director Sep 2003 Advantage Insurance Service Co., Ltd. (now Advantage Risk Management Co., Ltd.), Representative Director, Executive Vice President Oct 2007 Zaiosoft Co., Ltd., Managing Executive Officer, CFO and Head of President's Office Jan 2008 Zaiosoft Co., Ltd., Director, CFO May 2011 PRISM BioLab Co., Ltd. (now the Company), Executive Officer, CFO Dec 2012 the Company, Director, CFO Dec 2016 the Company, Representative Director (current)

Oct 2000 Novartis Pharma K.K., joined Sep 2008 Novartis Institutes for BioMedical Research (NIBR) Inc., joined Oct 2011 Laquoria Sōyaku Co., Ltd., joined Sep 2021 the Company, joined Jan 2022 the Company, Director, Head of Research and Development Department (current)

Apr 1997 Koga Sogo Law Office, joined Apr 2000 Nishimura & Asahi, joined Jan 2006 Ito Mitomi Law Office (now Morrison & Foerster Law Office), joined Apr 2011 Novartis Pharma K.K., joined Jul 2012 Sandoz K.K., joined Jul 2014 Novartis Pharma K.K., joined Jun 2015 Novartis Pharma K.K., Executive Officer and General Manager, Legal and Intellectual Property Division Apr 2022 Alnylam Japan K.K., Head of Legal Department Apr 2022 the Company, Outside Director (current) Dec 2023 Celljon Co., Ltd., Outside Audit & Supervisory Board Member Jun 2025 Isshiki Law Office, Gaikokuho Joint Enterprise, Partner (current) Jun 2025 MDM Co., Ltd., Outside Director (current)

Apr 1981 House Foods Industrial Co., Ltd. (now House Foods Corporation), joined Feb 1990 Sapporo Breweries Ltd. (now Sapporo Holdings Ltd.), joined Jan 1997 Sapporo Beverage Co., Ltd. (now Pokka Sapporo Food & Beverage Ltd.), seconded Sep 2005 Sapporo Beverage Co., Ltd., Executive Officer Jan 2008 Sapporo Beverage Co., Ltd., Director, Managing Executive Officer; Representative Director, Stella Beverage Service Co., Ltd. May 2010 Sapporo Beverage Co., Ltd., Director, Managing Executive Officer; Representative Director, Star Beverage Service Co., Ltd. Mar 2011 Sapporo Beverage Co., Ltd., Representative Director, Senior Managing Executive Officer Mar 2012 Sapporo Beverage Co., Ltd., Representative Director, Senior Managing Executive Officer; Outside Director, Pokka Corporation Jan 2013 Pokka Sapporo Food & Beverage Ltd., Managing Director Mar 2015 Pokka Sapporo Food & Beverage Ltd., Director, Managing Executive Officer Sep 2015 Pokka Sapporo Food & Beverage Ltd., Director, Managing Executive Officer; Representative Director, PS Beverage Co., Ltd. Mar 2016 Pokka Sapporo Food & Beverage Ltd., Audit & Supervisory Board Member Jun 2016 Pokka Sapporo Food & Beverage Ltd., Audit & Supervisory Board Member; Audit & Supervisory Board Member, Star Beverage Service Co., Ltd. Mar 2017 Pokka Sapporo Food & Beverage Ltd., Audit & Supervisory Board Member; Audit & Supervisory Board Member, Star Beverage Service Co., Ltd.; Audit & Supervisory Board Member, Sapporo Real Estate Development Co., Ltd. Jun 2017 Pokka Sapporo Food & Beverage Ltd., Audit & Supervisory Board Member; Audit & Supervisory Board Member, Star Beverage Service Co., Ltd. and Sapporo Real Estate Development Co., Ltd.; Outside Director, KeiAi Co., Ltd. Apr 2018 KeiAi Co., Ltd., joined Jun 2018 KeiAi Co., Ltd., Senior Managing Director Jun 2019 KeiAi Co., Ltd., Representative Director Jan 2022 the Company, Full-time Audit & Supervisory Board Member (current)

Oct 1995 Chuo Audit Corporation, joined Apr 2004 Shimizu International Patent Office (now Symphonia Intellectual Property Office), joined Feb 2010 Tajima Certified Public Accountant Office, Representative (current) Jul 2010 Registered as Certified Tax Accountant (current) Apr 2013 Quantum Bio Systems Co., Ltd., Outside Audit & Supervisory Board Member Sep 2014 PRISM Pharma Co., Ltd. (now the Company), Outside Audit & Supervisory Board Member (current) Sep 2014 Oncotherapy Science, Inc., Outside Audit & Supervisory Board Member (current) Aug 2015 Iida Foundation, General Incorporated Foundation, Auditor (current) Dec 2015 Tajima Accounting Office Co., Ltd., Representative Director (current) Jan 2016 Edigene Inc. (now Modalis Therapeutics Corporation), Outside Audit & Supervisory Board Member Mar 2016 Caiome Bioscience Co., Ltd., Outside Audit & Supervisory Board Member Mar 2016 Rena Therapeutics Inc., Outside Audit & Supervisory Board Member (current) Mar 2016 OiDE CapiSEA Co., Ltd., Accounting Advisor Jun 2016 Wendy's Japan Co., Ltd., Outside Audit & Supervisory Board Member (current) Jul 2016 Curadim Pharma Co., Ltd., Outside Audit & Supervisory Board Member Dec 2016 Obunsha Co., Ltd., Outside Audit & Supervisory Board Member (current) Mar 2017 OiDE Adjubilee Co., Ltd., Accounting Advisor Mar 2018 OiDE RYO-UN Co., Ltd., Accounting Advisor Aug 2018 Edigene Inc. (now Modalis Therapeutics Corporation), Outside Director (Audit and Supervisory Committee Member) (current) Sep 2018 OiDE CapiSEA Co., Ltd., Representative Liquidator Sep 2018 NewGen Pharma Co., Ltd., Outside Audit & Supervisory Board Member (current) Sep 2018 the Company, Outside Audit & Supervisory Board Member (current) Oct 2018 S'UIMIN Co., Ltd., Outside Audit & Supervisory Board Member Oct 2018 OiDE BetaRevive Co., Ltd., Accounting Advisor Jan 2019 Fujitsu Component Limited (now FCL Components Limited), Director (Audit Committee Member) (current) Mar 2020 OiDE OptoEye Co., Ltd., Accounting Advisor Feb 2021 J-Pharma Co., Ltd., Outside Audit & Supervisory Board Member Mar 2021 Tabata Inc., Outside Audit & Supervisory Board Member (current) Jan 2023 Longreach Business Partners Co., Ltd., Outside Audit & Supervisory Board Member (current) Jun 2023 Matsuya Foods Holdings Co., Ltd., Outside Audit & Supervisory Board Member (current) Jun 2023 MedMirai Co., Ltd., Outside Audit & Supervisory Board Member Aug 2023 nobitel Co., Ltd., Outside Audit & Supervisory Board Member (current) Sep 2023 J-Pharma Co., Ltd., Outside Director (Audit and Supervisory Committee Member) (current) Jul 2024 Shinnihon Jutaku Co., Ltd., Outside Audit & Supervisory Board Member (current) Jul 2024 Shinnihon PLUSIE Co., Ltd., Outside Audit & Supervisory Board Member (current) Jul 2024 S-Grad Co., Ltd., Outside Audit & Supervisory Board Member (current) Mar 2025 Shinnihon Jutaku Holdings Co., Ltd., Outside Audit & Supervisory Board Member (current)

Apr 1984 Kamigumi Co., Ltd., joined Jan 1989 Touche Ross & Co., joined Sep 1990 Deloitte & Touche LLC (now Deloitte Tohmatsu LLC), joined Aug 1993 Licensed as US Certified Public Accountant (California) Nov 1995 Nippon Express U.S.A., Inc., joined Sep 2001 Tohmatsu & Co., joined Oct 2004 Industrial Revitalization Corporation of Japan, joined May 2005 Deloitte Tohmatsu Financial Advisory LLC, Senior Vice President Mar 2009 Laquoria Sōyaku Co., Ltd., Executive Officer Mar 2012 Laquoria Sōyaku Co., Ltd., Managing Executive Officer Mar 2016 Laquoria Sōyaku Co., Ltd., Director, Senior Managing Executive Officer Apr 2017 Temrick Co., Ltd., Director Dec 2018 Laquoria Innovations Co., Ltd., Representative Director Mar 2020 Laquoria Sōyaku Co., Ltd., Director, Managing Executive Officer Apr 2021 the Company, Outside Audit & Supervisory Board Member (current) Oct 2021 3KR Ventures LLC, Managing Representative (current) Sep 2023 Crafton Biotechnology Co., Ltd., Outside Director (current) Dec 2023 Serve Biopharma Co., Ltd., Outside Audit & Supervisory Board Member (current) Apr 2025 Crafton Biotech U.S.A. Inc., Outside Director (current) Aug 2025 DLR Pharma Co., Ltd., Outside Director (current)

Apr 1984 Takeda Pharmaceutical Company Limited, joined Jul 1997 Takeda U.K. Ltd., seconded as Head of Finance Aug 2000 Takeda Pharmaceutical Company Limited, returned Jun 2004 Takeda Pharmaceutical Company Limited; Part-time Audit & Supervisory Board Member, Takeda Foods Industry Co., Ltd. (now House Wellness Foods Corporation) Jun 2005 Takeda Pharmaceutical Company Limited; Part-time Audit & Supervisory Board Member, Yamato Tokushu Glass Co., Ltd. Jun 2013 Takeda Pharmaceutical Company Limited; Part-time Audit & Supervisory Board Member, Mizusawa Chemical Industries, Ltd. and Takeda Real Estate Co., Ltd. (now Takeda Pharmaceutical Company Limited) Jun 2015 Takeda Pharmaceutical Company Limited; Part-time Audit & Supervisory Board Member, Wako Pure Chemical Industries, Ltd. (now FUJIFILM Wako Pure Chemical Corporation) Apr 2017 Takeda Consumer Healthcare Co., Ltd. (now Alinamin Pharmaceutical Co., Ltd.), seconded Jun 2017 Takeda Pharmaceutical Company Limited; Part-time Audit & Supervisory Board Member, Takeda Healthcare Co., Ltd. (now Alinamin Pharmatech Co., Ltd.) Apr 2023 the Company, Outside Audit & Supervisory Board Member (current)