Apr 1983 Joined Mitsubishi Kasei Corporation (currently Mitsubishi Chemical Group Corporation) Apr 1990 Pharmaceutical Division, Tokyo Branch, Mitsubishi Kasei Corporation Oct 1993 Pharmaceutical Business Division, Pharmaceutical Operations Headquarters, Mitsubishi Kasei Corporation Oct 1998 Seconded to Tokyo Tanabe Co., Ltd. (currently Mitsubishi Tanabe Pharma Corporation), Medical Information Department Oct 1999 Group Manager, Medical Information Department, Pharmaceutical Operations Headquarters, Mitsubishi Tokyo Pharmaceuticals, Inc. (currently Mitsubishi Tanabe Pharma Corporation) Oct 2001 Group Manager, Sales Planning Department, Sales Headquarters, Mitsubishi Pharma Corporation (currently Mitsubishi Tanabe Pharma Corporation) Apr 2005 General Manager, Kansai Area Marketing Department, Sales Headquarters, Mitsubishi Pharma Corporation Oct 2007 Senior Manager, Sales Promotion Department, Sales Headquarters, Mitsubishi Tanabe Pharma Corporation Apr 2008 General Manager, Product Development Department I, Sales Headquarters, Mitsubishi Tanabe Pharma Corporation Apr 2010 General Manager, Product Information Department, Sales Headquarters, Mitsubishi Tanabe Pharma Corporation Oct 2015 General Manager, Tokyo Branch, Sales Headquarters, Mitsubishi Tanabe Pharma Corporation Apr 2016 Executive Officer, General Manager, Tokyo Branch, Sales Headquarters, Mitsubishi Tanabe Pharma Corporation Apr 2017 Group Executive Officer, President, Yoshitomi Pharmaceutical Industries, Ltd. Apr 2018 Group Executive Officer, General Manager, Tianjin Tanabe Pharmaceutical Co., Ltd. Dec 2020 Director of the Company Apr 2021 Director and Vice President of the Company Apr 2022 Representative Director, President (current)

Sep 1992 Section Manager, Market Development Promotion Department, HOYA Corporation (Head Office) Oct 1994 Senior Managing Director, Core Medical Co., Ltd. Oct 1995 Founded the Company; Representative Director, President Sep 2002 Representative Director, CEO Oct 2011 Representative Director, President Oct 2013 Director, Chairman Oct 2014 Representative Director, Chairman and President Oct 2015 Representative Director, Chairman and President, and Head of Business Division Oct 2018 Representative Director, Chairman and President Dec 2018 Representative Director, President Apr 2022 Representative Director, Chairman Dec 2024 Director, Chairman (current)

Apr 1997 Joined Chiyoda Life Insurance Company (currently Gibraltar Life Insurance Co., Ltd.) Feb 2001 Joined Marubeni Telecom Co., Ltd. (currently MX Mobiling Co., Ltd.) Sep 2004 Joined the Company Oct 2006 Group Manager, Corporate Planning Group, Corporate Planning Department Dec 2007 Director, Tokyo Bay Medical Frontier Co., Ltd. Oct 2011 General Manager, Administration Division, Koshikai Medical Corporation Jan 2018 General Manager, Management Administration Department, the Company Dec 2018 Director, General Manager of Management Administration Department (current)

Jun 2000 Joined Ain Engineering Co., Ltd. Apr 2003 Joined the Company Jan 2008 Group Manager, Clinical Development Group, Clinical Development Department Oct 2014 Head of Academic Development Office, TR Promotion Department Apr 2015 General Manager, Business Strategy Department Dec 2018 Director, General Manager of Business Strategy Department Apr 2020 Director, General Manager of Cell Processing Business Division (current)

Apr 1985 Joined Komatsu Ltd. May 1989 Joined Nikko Securities Co., Ltd. (currently SMBC Nikko Securities Inc.) Dec 1998 Joined Dresdner Kleinwort Benson Securities; Head of Equity Finance, Asia Sep 2000 Joined ING Barings Securities; Head of Equity Finance, Asia-Oceania Mar 2003 Representative Director, T&R Co., Ltd. (currently T&R Holdings Inc.) (current) Jun 2003 Joined BNP Paribas Securities (Japan) Ltd.; Head of Equities and Derivatives Apr 2007 Director, Aristagora Co., Ltd. (currently Aristagora Advisors Co., Ltd.) Mar 2011 Chairman and Representative Director, Aristagora Co., Ltd. (current) Sep 2013 Director, Aristagora Financial Services Co., Ltd. Oct 2014 Outside Director, Noah's Planning Co., Ltd. Oct 2014 Outside Director, the Company (current) Jan 2016 Chairman, Aristagora Financial Services Co., Ltd. (current) Aug 2017 Chairman of the Board, Aristagora International Pte. Ltd. (Singapore) Jan 2018 Director, Aristagora International Pte. Ltd. (current) Nov 2018 Director, Aristagora Asset Management Pte. Ltd. (Singapore) (current) Jan 2020 Director, Aristagora VC Israel GP Ltd. (Cayman Islands) (current) Dec 2020 Director, Nichiryoku Co., Ltd.; Chairman of the Board, same company (current) Jun 2022 Director (current)

Apr 1974 Joined Kanebo, Ltd. Jul 1987 Group Leader, Synthetic Research Group, Pharmaceutical Research Laboratory, Kanebo, Ltd. Sep 1991 Group Leader, First Cancer Research Group, Cancer Research Institute, Kanebo, Ltd. Apr 1998 General Manager, Resource Exploration Research Department, Drug Discovery Research Institute, Kanebo, Ltd. Apr 1999 Joined Nippon Organon K.K. (currently MSD K.K.); Head of Pharmaceutical Research Institute Apr 2003 Founded Carna Biosciences, Inc.; Representative Director, President (current) Apr 2003 Outside Director, the Company (current) Dec 2018 Outside Director, Kringle Pharma, Inc. (current)

Apr 1970 Joined Yamanouchi Pharmaceutical Co., Ltd. (currently Astellas Pharma Inc.), Research and Development Division Aug 1994 Medical Sales Headquarters, Yamanouchi Pharmaceutical Co., Ltd. Jun 1998 Director, Yamanouchi Pharmaceutical Co., Ltd. Jun 1999 Director, Head of Sales Headquarters, Yamanouchi Pharmaceutical Co., Ltd. Jun 2002 Senior Managing Director, Yamanouchi Pharmaceutical Co., Ltd. Jun 2003 Executive Vice President, Yamanouchi Pharmaceutical Co., Ltd. Apr 2005 Executive Vice President, Head of Sales Headquarters, Astellas Pharma Inc. Sep 2008 Joined CMIC Co., Ltd. (currently CMIC Holdings Co., Ltd.) Dec 2010 Representative Director, Injex Japan Co., Ltd. (established) May 2013 Representative Director, Orphan Pacific Inc., subsidiary of CMIC Holdings Co., Ltd. Oct 2013 Representative Director and Vice Chairman, CMIC Holdings Co., Ltd.; Advisor, Medipal Holdings Corporation Jul 2017 Advisor, Kimura Information Technology Co., Ltd. Apr 2019 Advisor, Quantum Operation Co., Ltd. (current) Oct 2020 Representative Director, Sygject Co., Ltd. (established) (current) Dec 2022 Outside Director, the Company (current)

Apr 1987 Joined American Family Life Assurance Company of Columbus Japan Ltd. (currently Aflac Life Insurance Japan Ltd.) Feb 2004 Joined AIG Star Life Insurance Co., Ltd.; Marketing Manager, Customer Strategy Division Mar 2005 Director, Sun Holdings Corporation Apr 2009 Representative Director, President, Sun Holdings Corporation (concurrently Representative Director, President, Koeisha Co., Ltd.) Aug 2016 Vice President Executive Officer and COO, Popins Inc. Jul 2017 Director, Fukoku Bussan Co., Ltd. Apr 2018 Vice President Director, Fukoku Bussan Co., Ltd. Apr 2019 Auditor, Mirai Gakuen Educational Corporation (current) Jun 2019 Founded Keiei Design Partners Inc.; Representative Director, President (current) Jun 2019 Director, Nichiryoku Co., Ltd. (current) Jun 2022 Director, CEO Kids Academy Co., Ltd. (current) Dec 2022 Outside Director, Hanada Kouumuten Co., Ltd. (current) May 2025 Outside Director, Body Sprout Co., Ltd. (current) Dec 2025 Full-time Outside Corporate Auditor of the Company (current)

Apr 1982 Registered as attorney-at-law (Class 34); joined Kuroda Law Office Apr 1984 Established own law office after becoming independent May 2018 Partner, Oku, Katayama & Sato Law Office (current) Dec 2018 Outside Corporate Auditor of the Company Jun 2019 Director, NC Holdings Co., Ltd. Jun 2022 Director (Audit and Supervisory Committee Member), NC Holdings Co., Ltd. (current) Jan 2025 Full-time Outside Corporate Auditor of the Company Dec 2025 Outside Corporate Auditor of the Company (current)

Apr 1978 Joined Kanebo, Ltd. Dec 1981 Group Leader, Formulation Development Research Department, Kanebo, Ltd. Sep 1988 Chemistry Group, Research Department, Medicinal Research and Development Division, Schering K.K. (currently Bayer Yakuhin, Ltd.) Jul 1989 Head of New Drug Development Office, Pharmaceutical Research Group, Research Department, Medicinal Research and Development Division, Schering K.K. Apr 1995 Group Leader, Pharmaceutical Research Group, Research Department, Research and Development Division, Schering K.K. Aug 2004 General Manager, Safety and Regulatory Affairs Department, Schering K.K. Jan 2005 Executive Officer, General Manager, Reliability Assurance Department, and General Product Manufacturing and Marketing Manager, Schering K.K. Jul 2007 General Manager, Quality Assurance Department, Alcon Japan Ltd. Feb 2008 General Manager, Reliability Assurance Department, and General Manager, Quality Assurance Department, Alcon Japan Ltd.; General Product Manufacturing and Marketing Manager Dec 2011 General Manager, Reliability Assurance Office, AstraZeneca K.K.; General Product Manufacturing and Marketing Manager Apr 2015 General Product Manufacturing and Marketing Manager, Baxalta Japan Ltd. (currently Takeda Pharmaceutical Company Limited) Jul 2017 CMC and Regulatory Affairs, YAKUMED Limited (current) Dec 2020 Outside Corporate Auditor of the Company (current) Mar 2022 General Product Manufacturing and Marketing Manager, Swedish Orphan Biovitrum Japan K.K. Jul 2023 Quality Assurance, Biocomo Co., Ltd.