Apr 2012 GlaxoSmithKline Vaccines: President and General Manager Apr 2012 GlaxoSmithKline Biologicals: Chief Executive Officer Apr 2012 GlaxoSmithKline plc: Corporate Executive Team Member Apr 2014 Chief Operating Officer Jun 2014 Representative Director, President Apr 2015 Chief Executive Officer (current) Sep 2020 Global Business Head, Takeda Pharmaceuticals U.S.A., Inc. (current) Feb 2026 Outside Director, Boston Scientific Corporation (current)

Apr 2000 Joined Industrial Bank of Japan, Ltd. (currently Mizuho Financial Group) Jun 2006 Joined Taiyo Pacific Partners (U.S.) Jul 2010 Joined Takeda Jun 2017 Country Manager, Takeda Farmaceutiska AB (Sweden) Jan 2019 Corporate Strategy Officer and Chief of Staff Apr 2021 President, Japan Pharma Business Unit Apr 2024 Chief Financial Officer (current) Jun 2024 Director (current)

Jan 2008 Vice President, Merck & Co., Inc.; Global Head of Cardiovascular Disease Discovery Mar 2014 Senior Vice President, Sanofi; Deputy Head of Research and Translational Medicine Feb 2015 Chief Medical and Scientific Officer-designate Jun 2015 Director (current) Jun 2015 Chief Medical and Scientific Officer Jan 2019 President, Research and Development (current) Jul 2021 President, Research and Development, Takeda Development Center Americas, Inc. (current)

Jun 2008 Representative Director, Managing Executive Officer, Mitsui & Co., Ltd. Oct 2008 Representative Director, Senior Managing Executive Officer, Mitsui & Co., Ltd. Apr 2009 Representative Director, President, Mitsui & Co., Ltd. Apr 2015 Representative Director, Chairman, Mitsui & Co., Ltd. Jun 2018 Outside Director, SoftBank Group Corp. (current) Jun 2019 Counselor, Bank of Japan (current) Apr 2021 Director, Mitsui & Co., Ltd. Jun 2021 Advisor, Mitsui & Co., Ltd. (current) Jun 2021 Outside Director (Audit and Supervisory Committee Member) Jun 2022 Outside Director (current) Jun 2022 Chair of the Board (current) Jun 2023 Outside Director, Kajima Corporation (current)

Jan 2010 Director, Chief Executive Officer and Head of North American Commercial Operations, Genentech, Inc. Jan 2017 Outside Director, Shire plc Jan 2017 Outside Director, Corvus Pharmaceuticals, Inc. (current) Jan 2017 Outside Director, Guardant Health, Inc. (current) Jan 2019 Outside Director (current) Aug 2020 Outside Director, Olema Pharmaceuticals, Inc. (current) Sep 2021 Outside Director, Kymera Therapeutics, Inc. (current) Aug 2025 Outside Director, BioMarin Pharmaceutical Inc. (current)

Aug 1981 Founder, Director and Executive Vice President, Research and Development, Immunex Corporation (currently Amgen Inc.) May 1993 Chief Executive Officer, Immunex Corporation Oct 1994 Founder, Director and Chief Executive Officer, Corixa Corporation (currently GSK plc) Jan 1999 Director and Chairman, Corixa Corporation Aug 2005 Managing Director, ARCH Venture Partners (current) Oct 2012 Outside Director, Shire plc Jan 2019 Outside Director (current)

May 1994 Managing Director, Investment Banking, Merrill Lynch & Co., Inc. Apr 2000 Chief Executive Officer, Gillo Ventures, Inc. Jan 2003 Managing Director, Higashi Partners, Inc. (current) Nov 2010 Outside Director, KLA-Tencor Corporation (currently KLA Corporation) (current) Jun 2016 Outside Director May 2017 Outside Director, Lam Research Corporation (current) Jun 2019 Outside Director (Audit and Supervisory Committee Member) Mar 2023 Outside Director, Rapidus Corporation (current) Jun 2024 Outside Director (current)

Apr 2000 Senior Vice President, Strategic Product Development, Millennium Pharmaceuticals, Inc. Dec 2002 Director and Chief Executive Officer, Alnylam Pharmaceuticals, Inc. Jun 2017 Chair, Biotechnology Innovation Organization Nov 2021 Outside Director, Beam Therapeutics Inc. Jan 2022 Principal and Chief Executive Officer, JMM Innovations (current) Feb 2022 Outside Director, Kymera Therapeutics, Inc. (current) Jun 2022 Outside Director (current) Mar 2024 Outside Director, Rapport Therapeutics, Inc. (current) Sep 2025 Co-Chief Executive Officer, Corsera Health (current)

Mar 2001 Global Head, Over-the-Counter Business, Novartis AG Apr 2007 President and Chief Executive Officer, Synthes, Inc. (currently Johnson & Johnson) Jun 2012 Chairman, Global Orthopaedics, DePuy Synthes, Johnson & Johnson Jun 2012 Member, Global Management Team, Johnson & Johnson Jun 2016 Outside Director Jun 2019 Outside Director (Audit and Supervisory Committee Member) Jun 2022 Outside Director (current)

May 1995 Partner and Managing Director, The Boston Consulting Group May 2003 Senior Partner and Managing Director, The Boston Consulting Group May 2005 Leader, Marketing, Sales and Pricing Group, The Boston Consulting Group Oct 2011 Member, Executive Committee, The Boston Consulting Group Jun 2013 Chief Marketing Officer, The Boston Consulting Group Feb 2023 Representative Director, President, Microsoft Japan Co., Ltd. (current) Jun 2023 Outside Director (current)

Mar 1974 Joined Price Waterhouse Jul 1991 Managing Partner, Aoyama Audit Corporation Oct 2005 Director, International Business Management Department, Chuo Aoyama PricewaterhouseCoopers May 2009 Representative Executive Officer and Chief Executive Officer, Asahi Audit Corporation Jun 2013 Outside Audit & Supervisory Board Member, Fujitsu Limited (current) Jun 2016 Outside Director (Audit and Supervisory Committee Member) Jun 2019 Outside Director (Chair of the Audit and Supervisory Committee) (current)

Jan 1998 Corporate Officer and President, Global Over-the-Counter Business, Becton, Dickinson and Company Nov 1999 President, Johnson & Johnson Independent Technology May 2008 Corporate Officer, Executive Committee Member and Executive Vice President, Group President, International Business, Medtronic plc Jan 2015 President, International Business, Baxter International Inc. Jul 2015 Global Healthcare Advisor and President, K8 Global (current) Jun 2016 Outside Director (Audit and Supervisory Committee Member) Jun 2019 Outside Director Sep 2021 Outside Director, Lani Therapeutics (current) Jun 2024 Outside Director (Audit and Supervisory Committee Member) (current)

May 2001 Senior Vice President, General Electric Company Mar 2011 Representative Director, Chairman, GE Japan Corporation Aug 2011 Representative Director, President and Chief Executive Officer, LIXIL Corporation Aug 2011 Director, Representative Executive Officer, President and Chief Executive Officer, LIXIL Group Corporation Jan 2016 Representative Director, Chairman and Chief Executive Officer, LIXIL Corporation Jun 2016 Outside Director Jul 2016 Outside Director, Boston Scientific Corporation (current) Feb 2017 Senior Advisor, CVC Asia Pacific Japan K.K. (current) Aug 2018 Outside Director and Chairman, Oracle Corporation Japan (current) Jun 2019 Outside Director, Rireku Inc. (current) Jun 2022 Outside Director (Audit and Supervisory Committee Member) (current) Jul 2022 Outside Director, Tri-Group Co., Ltd. (current)

Oct 1997 Attorney, Committee on Financial Services, U.S. House of Representatives May 2004 Senior Advisor to the Secretary, U.S. Department of the Treasury Feb 2007 Director and Chief Executive Officer, Community Development Financial Institutions Fund, U.S. Department of the Treasury Dec 2007 Vice President, Financial Market Policy, Lehman Brothers Holdings Inc. Sep 2009 President, International Food Information Council Foundation May 2019 Chair of the Board, President and Chief Executive Officer, Export-Import Bank of the United States Feb 2021 Senior Fellow, Council on Competitiveness (U.S.) (current) Aug 2021 Outside Director, Momentus Inc. (current) Jun 2022 Outside Director (Audit and Supervisory Committee Member) (current) Mar 2023 Outside Director, Hannon Armstrong Sustainable Infrastructure Capital, Inc. (current)