Jan 1980: Representative Director and President, Nihon Bio-Rad Laboratories, Inc. Jul 1991: Representative Director and President, Nihon Syntex Corporation May 1993: Representative Director and President, Amgen K.K. Amgen Inc. (U.S.): Vice President Mar 2005: Founded the Company; Representative Director, President and CEO (current)

Apr 1981: Joined Sumitomo Chemical Co., Ltd. Dec 2003: Seconded to Sumitomo Pharmaceuticals Co., Ltd. Jan 2008: Transferred to Dainippon Sumitomo Pharma Co., Ltd. (now Sumitomo Pharma Co., Ltd.) Jun 2008: Executive Officer, Dainippon Sumitomo Pharma Co., Ltd. Jun 2012: Director and Executive Officer, Dainippon Sumitomo Pharma Co., Ltd. Apr 2014: Director and Managing Executive Officer, Dainippon Sumitomo Pharma Co., Ltd. Apr 2016: Director and Senior Managing Executive Officer, Dainippon Sumitomo Pharma Co., Ltd. Apr 2017: Representative Director and Senior Managing Executive Officer, Dainippon Sumitomo Pharma Co., Ltd. Apr 2018: Representative Director, President, Dainippon Sumitomo Pharma Co., Ltd. Jun 2024: Special Advisor, Dainippon Sumitomo Pharma Co., Ltd. Mar 2026: Outside Director, the Company (current)

Jul 1971: Intern, Internal Medicine, University of Virginia Hospital Jul 1973: Senior Assistant Resident, Internal Medicine, University of Virginia Hospital Jul 1974: Clinical Research Fellow, Hematology, New England Medical Center Hospitals Jul 1977: Assistant Professor, Hematology/Oncology, School of Medicine, University of Utah Hospital Oct 1984: Senior Investigator, Cancer Therapy Evaluation Program, National Cancer Institute Jun 2001: Scientific Advisor, Lymphoma Research Foundation Jul 2002: Associate Chief, Division of Hematology-Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital Mar 2013: Director, Hematology-Oncology Fellowship Program, Georgetown University Hospital Aug 2016: Outside Director, MorphoSys AG Dec 2018: Chair, Hematology-Oncology Committee, Frank M. Irwing Foundation Mar 2019: Outside Director, the Company (current) May 2021: Physician, Cancer and Blood Disorders Center May 2025: Lymphoma Consultant (current)

Mar 1991: Senior Vice President, Global Development and Chief Medical Officer, Amgen Inc. (U.S.) Apr 2006: Chief Executive Officer, G&R Morstein Partners Ltd. (current) Mar 2009: Outside Director, the Company Jul 2010: Deputy Chairman, Victorian Comprehensive Cancer Centre (Australia) Dec 2017: Outside Director, Actinogen Medical Ltd. (Australia) (current) Mar 2019: Outside Director, the Company (resigned) May 2021: Independent Director, PioTx Ltd. (Australia) (current) Mar 2024: Outside Director, the Company (current)

Jun 2003: Vice President, Global R&D Policy and Analysis, Amgen Inc. (U.S.) Aug 2005: Principal Consultant, Linas Consulting LLC (U.S.) (current) Jan 2006: Lecturer, California State University, Channel Islands (U.S.) Jun 2006: Director, Direct Access Residential Energy (U.S.) Jul 2023: Vice President and Head of Regulatory Affairs, Genelux Corporation (U.S.) (current) Mar 2025: Outside Director, the Company (current)

Apr 1982: Joined Japan Petroleum Exploration Co., Ltd. Jul 2006: General Manager, Public Relations and IR Department, Japan Petroleum Exploration Co., Ltd. Jul 2008: General Manager, Overseas Planning Office, Overseas Division, Japan Petroleum Exploration Co., Ltd. Jun 2009: General Manager, Overseas Division No. 1, Japan Petroleum Exploration Co., Ltd. Jun 2011: General Manager, Canada Oil Sands Project Department, Americas and Russia Business Division, Japan Petroleum Exploration Co., Ltd. Jun 2012: Assistant to General Manager, Americas and Russia Business Division, Japan Petroleum Exploration Co., Ltd. Jun 2017: Assistant to General Manager, Middle East, Africa and Europe Business Division, Japan Petroleum Exploration Co., Ltd. Jun 2018: Full-time Audit & Supervisory Board Member, Japan Petroleum Exploration Co., Ltd. Jun 2022: Full-time Audit & Supervisory Board Member, Nihon Kaiyo Sekiyu Shigen Kaihatsu Co., Ltd. Jan 2024: Head of Legal Affairs, HW ELECTRO Co., Ltd. Mar 2025: Outside Director (Audit and Supervisory Committee Member), the Company (current)

Oct 1981: Joined Shinwa Audit Corporation (now Azsa LLC) Mar 1985: Registered as Certified Public Accountant May 2003: Partner, Azsa LLC Sep 2010: Executive Director, Azsa LLC Apr 2014: Head of Quality Control Division, Azsa LLC Nov 2015: Chair, Senior Review Committee, Azsa LLC Jun 2021: Outside Audit & Supervisory Board Member, J-Oil Mills, Inc. Jul 2021: Principal, Eiji Mizutani Certified Public Accountant Office (current) Jun 2022: Outside Audit & Supervisory Board Member, Obayashi Corporation (current) Mar 2026: Outside Director (Audit and Supervisory Committee Member), the Company (current)

Dec 2004: Joined Azsa LLC Jul 2008: Registered as Certified Public Accountant Dec 2014: Registered as Attorney-at-Law; joined Ogasawara Rokukawa International Law Office Jul 2015: Joined Hanzomon Law Office Jan 2017: Ichinozawa Law Office (current) Jun 2020: Outside Audit & Supervisory Board Member, Solbrain Co., Ltd. (current) Oct 2020: Part-time Lecturer, Office of Industry-Academia Collaboration, University of Tsukuba (current) Mar 2022: Outside Director, FINES Co., Ltd. (current) Jun 2022: Chair, Nomination and Compensation Committee, FINES Co., Ltd. (current) Mar 2023: Part-time Audit & Supervisory Board Member, GMO OMAKASE Inc. (current) Dec 2023: Part-time Audit & Supervisory Board Member, Albirex Niigata Co., Ltd. (current) Mar 2026: Outside Director (Audit and Supervisory Committee Member), the Company (current)