Apr 1998 Joined the Company Apr 2010 General Manager, Development Department, the Company Apr 2014 Executive Officer, General Manager, Development Department, Technology Division, the Company Apr 2016 Executive Officer, Deputy General Manager, R&D Division, and General Manager, Development Department, the Company Apr 2018 Managing Executive Officer, General Manager, R&D Division, and General Manager, Development Department, the Company Jun 2018 Director, Managing Executive Officer, General Manager, R&D Division, and General Manager, Development Department, the Company Apr 2022 Director, Managing Executive Officer, General Manager, R&D Division, and General Manager, Development Department, the Company Apr 2024 Director, Managing Executive Officer, General Manager, R&D Division, the Company Jun 2025 Representative Director, President, the Company (current)

Apr 1986 Joined Fuji Bank, Ltd. (now Mizuho Bank, Ltd.) Jan 2008 Branch Manager, Akita Branch, Mizuho Bank, Ltd. Oct 2010 Branch Manager, Adachi Branch, Mizuho Bank, Ltd. Feb 2013 Counselor, Kudanshita Branch, Mizuho Bank, Ltd. Jan 2017 Joined the Company, Executive Officer, General Manager, Accounting Department Apr 2018 Executive Officer, Deputy General Manager, Administration Division, and General Manager, Accounting Department, the Company Oct 2018 Managing Executive Officer, General Manager, Administration Division, and General Manager, Accounting Department, the Company Jun 2019 Director, Managing Executive Officer, General Manager, Administration Division, and General Manager, Accounting Department, the Company Jul 2021 Director, Senior Managing Executive Officer, General Manager, Administration Division, and General Manager, Accounting Department, the Company Apr 2025 Director, Senior Managing Executive Officer, General Manager, Administration Division, the Company Jun 2025 Representative Director, Vice President, General Manager, Administration Division, the Company (current)

Apr 1987 Joined Fuji Bank, Ltd. (now Mizuho Bank, Ltd.) Jan 2018 Joined the Company Jan 2019 Executive Officer, Business Strategy Office, Corporate Planning Department, the Company Apr 2020 Executive Officer, General Manager, Corporate Planning Department, the Company Jul 2021 Managing Executive Officer, General Manager, Corporate Planning Department, the Company Aug 2022 Managing Executive Officer, in charge of Overseas Business Division, and General Manager, Business Strategy Department, the Company Apr 2023 Managing Executive Officer, in charge of International Business Division, and General Manager, Overseas Administration Department, the Company Jun 2025 Director, Managing Executive Officer, General Manager, International Business Division, the Company (current)

Apr 1992 Joined the Company Apr 2008 General Manager, Production Department, and General Manager, Technology Department, Technology Division, the Company Apr 2013 Executive Officer, General Manager, Production Department, and General Manager, Technology Department, Technology Division, the Company Oct 2015 Executive Officer, General Manager, Production Technology Division, General Manager, Production Department, and General Manager, Technology Department, the Company Apr 2016 Managing Executive Officer, General Manager, Production Technology Division, General Manager, Production Department, and General Manager, Technology Department, the Company Jun 2017 Director, Managing Executive Officer, General Manager, Production Technology Division, General Manager, Production Department, and General Manager, Technology Department, the Company Apr 2018 Director, Managing Executive Officer, General Manager, Production Technology Division, the Company Apr 2024 Director, Managing Executive Officer, General Manager, Production Technology Division, and General Manager, Production Management Department, the Company Apr 2025 Director, Managing Executive Officer, General Manager, Production Technology Division, the Company (current)

Apr 1988 Joined the Company Jan 2019 General Manager, Clinical Research Department, the Company Apr 2020 General Manager, Academic Affairs Department, the Company Jul 2021 Executive Officer, General Manager, Academic Affairs Department, the Company Jun 2024 Director, Executive Officer, Deputy General Manager, R&D Division, and General Manager, Academic Affairs Department, the Company Jun 2025 Director, Managing Executive Officer, General Manager, R&D Division, and General Manager, Academic Affairs Department, the Company (current)

Apr 2013 Joined the Company, Executive Officer, General Manager, CL Sales Department, Sales Division Apr 2022 Executive Officer, General Manager, Eye Care Sales Department, Sales Division, the Company Apr 2026 Executive Officer, Deputy General Manager, Sales Division, the Company Jun 2026 Director, Managing Executive Officer, General Manager, Sales Division, the Company (current)

Apr 1996 Joined Odai Accounting Office Jun 1999 Registered as Certified Public Accountant Jul 2000 Joined Mizuho Corporate Advisory Co., Ltd. May 2006 Established Pro Vitas Co., Ltd., Representative Director (current) Jul 2006 Registered as Certified Tax Accountant; opened Hiroko Otake CPA and Tax Accountant Office (current) Jun 2015 Director, the Company (current) Mar 2025 Outside Director, MCP Capital Co., Ltd. (current) Jun 2025 Outside Director (Audit and Supervisory Committee Member), Nippon Chemical Industrial Co., Ltd. (current)

Apr 1993 Joined the Company Jun 1996 Director, General Manager, Pharmaceutical and Cosmetics Department, Sales Division, the Company Jun 2000 Director, General Manager, Merchandise Department, the Company Apr 2006 Director, General Manager, Sales Division, the Company Jun 2008 Retired as Director; Advisor, the Company Jun 2009 Full-time Corporate Auditor, the Company (current)

Apr 1985 Joined the Company Apr 1998 General Manager, Eyeglasses Department, the Company Apr 2014 Executive Officer, General Manager, Related Business Division, the Company Apr 2016 Managing Executive Officer, General Manager, Merchandise Division, the Company Jul 2021 Managing Executive Officer, General Manager, Subsidiary Management Department, the Company Apr 2022 Managing Executive Officer, General Manager, Business Development Division, the Company Jun 2023 Director, Managing Executive Officer, General Manager, Sales Division, the Company Jun 2026 Full-time Corporate Auditor, the Company (current)

Mar 1994 Graduated from Faculty of Medicine, Kyoto Prefectural University of Medicine Mar 2000 Completed Graduate School of Medical Science, Kyoto Prefectural University of Medicine; Doctor of Medicine Oct 2000 Postdoctoral Researcher, Department of Ophthalmology, University of Cologne Oct 2003 Assistant Professor, Regenerative Medicine Research Center, Research and Development Promotion Organization, Doshisha University Apr 2008 Associate Professor, Faculty of Life and Medical Sciences, Doshisha University Apr 2010 Professor, Faculty of Life and Medical Sciences, Doshisha University (current); Visiting Professor, Faculty of Medicine, Kyoto Prefectural University of Medicine (current) Apr 2015 Clinical Professor, Faculty of Medicine, Kyoto University (current) Jun 2022 Director, the Company (current) Jul 2025 Director and Chief Scientific Officer, Actualize Co., Ltd. (current)

Apr 1984 Joined Mitsui & Co., Ltd. Oct 2008 General Manager, Business Development Division, Bussan Real Estate Co., Ltd. Oct 2009 Representative Director, President, Mitsui & Co. Logistics Partners Ltd. Jul 2012 General Manager, Urban Development Division, Mitsui & Co., Ltd. Apr 2017 Executive Officer, General Manager, Consumer Business Division, Mitsui & Co., Ltd. Apr 2019 President, Mitsui & Co. (Thailand) Ltd.; President, Mitsui & Co. (Thailand) Ltd. / Mitsui & Co., Ltd. Executive Officer Jun 2021 Full-time Corporate Auditor, Mitsui Information Co., Ltd. Jun 2025 Director, the Company (current)

Apr 1999 Joined Fuji Bank, Ltd. (now Mizuho Bank, Ltd.) Sep 2009 Completed Legal Training and registered as Attorney-at-Law Oct 2009 Joined Ohmellveny & Myers LLP (Foreign Law Joint Enterprise), Associate Sep 2014 Master of Laws, University of Oxford Jan 2016 Counsel, Ohmellveny & Myers LLP Mar 2019 Master of Laws (Advanced Intellectual Property Law), Graduate School of Law, Waseda University Jun 2019 Corporate Auditor, the Company (current) Jun 2022 Outside Director, Hokuetsu Corporation (current) Mar 2023 Outside Corporate Auditor, JUKI Corporation Mar 2025 Outside Director, JUKI Corporation (current) Jun 2025 Non-Executive Auditor, Tsuda University (current) Oct 2025 Managing Partner (Attorney-at-Law), Hillford Law Office (current)

Apr 1982 Joined The Hokkaido Takushoku Bank, Ltd. May 1989 Graduated from Cornell University Johnson Graduate School of Management; Master of Business Administration Apr 1994 Manager, London Branch, The Hokkaido Takushoku Bank, Ltd. Nov 1997 Joined Chuo Trust & Banking Co., Ltd. (now Sumitomo Mitsui Trust Bank, Limited) Oct 2006 General Manager, International Division, Chuo Mitsui Trust and Banking Co., Ltd. Jul 2009 General Manager, General Affairs Department, Chuo Mitsui Trust Holdings, Inc. (now Sumitomo Mitsui Trust Group, Inc.), and General Manager, General Affairs Department, Chuo Mitsui Trust and Banking Co., Ltd. (now Sumitomo Mitsui Trust Bank, Limited) Feb 2011 Executive Officer, Chuo Mitsui Loan Business Co., Ltd. (now Sumitomo Mitsui Trust Business Service Co., Ltd.) Apr 2015 Director, Tozai Land & Building Co., Ltd. Apr 2020 Head of Internal Audit Office, Dokkyo Gakuen School Corporation Jun 2021 Corporate Auditor, the Company (current)