Apr 1987 Joined the Company Oct 2008 General Manager, Life Cycle Management Dept. II, the Company Jun 2009 General Manager, Life Cycle Management Dept. II and Life Cycle Leader, the Company Apr 2011 President, Roche Products Ireland Oct 2013 Head of Oncology Unit, Sales Division, the Company Jan 2014 Executive Officer, Head of Oncology Unit, Sales Division, the Company Jan 2015 Executive Officer, General Manager, Corporate Planning Dept., the Company Apr 2017 Senior Executive Officer, General Manager, Corporate Planning Dept., the Company Apr 2018 Senior Executive Officer, Head of Project and Life Cycle Management Joint Unit, the Company Mar 2020 Representative Director, President and Chief Operating Officer (COO), the Company Mar 2021 Representative Director, President and Chief Executive Officer (CEO), the Company (current)

Apr 1989 Joined The Long-Term Credit Bank of Japan, Ltd. (now SBI Shinsei Bank, Limited) Jan 2004 Joined Takeda Pharmaceutical Company Limited Apr 2013 General Manager, Management Accounting Dept., Takeda Pharmaceutical Company Limited Apr 2015 General Manager, Finance Division, Takeda Pharmaceutical Company Limited Jan 2017 Joined Recruit Holdings Co., Ltd. as Executive Officer in charge of Finance, Accounting and Tax Apr 2018 Executive Officer in charge of Finance, Accounting and Tax, Recruit Holdings Co., Ltd.; Director, Recruit Co., Ltd. Aug 2022 Joined the Company as Senior Executive Officer, General Manager, Finance and Accounting Dept. Jan 2023 Senior Executive Officer, General Manager, Finance Division and Finance and Accounting Dept., the Company Mar 2024 Director, Senior Executive Officer and Chief Financial Officer (CFO), the Company (current)

Aug 2000 Joined the Company Apr 2017 General Manager, Medicinal Chemistry Research Dept., the Company Jan 2021 General Manager, Research Division, the Company Apr 2022 Executive Officer, General Manager, Research Division, the Company Jan 2024 Executive Officer, General Manager, Translational Research Division, the Company Mar 2024 Director, Senior Executive Officer, General Manager, Translational Research Division, the Company Jan 2026 Director, Senior Executive Officer, General Manager, Corporate Planning Dept., the Company (current)

Mar 2005 Joined the Company Jan 2016 General Manager, Pharmaceutical Planning Dept., the Company Apr 2018 General Manager, Management Dept., Chugai Pharmaceutical Co., Ltd. Jan 2019 General Manager, CSR Promotion Dept., the Company Apr 2019 General Manager, Sustainability Promotion Dept., the Company Jan 2023 General Manager, Human Resources Dept., the Company Mar 2023 Standing Audit & Supervisory Board Member, the Company (current)

Apr 1992 Joined the Company Oct 2013 General Manager, Regulatory Affairs Dept., the Company Apr 2019 General Manager, Reliability Assurance Planning Dept., the Company Jan 2021 Head of Reliability Assurance Unit, the Company Jan 2022 Executive Officer, Head of Reliability Assurance Unit, the Company Jan 2023 Executive Officer, Head of Reliability Assurance Unit, in charge of Risk & Compliance Dept., the Company Jan 2025 Executive Officer, the Company Mar 2025 Standing Audit & Supervisory Board Member, the Company (current)

Aug 1975 Joined Tateishi Electric Co., Ltd. (now Omron Corporation) Jun 1997 Director, Omron Corporation Jun 1999 Managing Executive Officer, Omron Corporation Jun 2001 General Manager, Group Strategy Office, Omron Corporation Jun 2003 Senior Managing Executive Officer and President, Industrial Automation Business Company, Omron Corporation Jun 2008 Director and Vice Chairman, Omron Corporation Jun 2013 Director and Chairman, Omron Corporation Mar 2023 Director, the Company (current) Jun 2023 Honorary Advisor, Omron Corporation (current) Principal concurrent position: Honorary Advisor, Omron Corporation

Apr 1983 Joined Dai-ichi Life Insurance Company, Limited Jun 2012 Director, Managing Executive Officer, Deputy Head of Group Management and General Manager, Corporate Planning Dept., Dai-ichi Life Insurance Company, Limited Apr 2013 Director, Managing Executive Officer, Deputy Head of Group Management, Dai-ichi Life Insurance Company, Limited Apr 2015 Director, Senior Managing Executive Officer, Head of Marketing Promotion Division, Dai-ichi Life Insurance Company, Limited Oct 2016 Director, Senior Managing Executive Officer, Head of Marketing Promotion Division, Dai-ichi Life Holdings, Inc.; Director, Senior Managing Executive Officer, Dai-ichi Life Insurance Company, Limited Apr 2017 Director, Dai-ichi Life Holdings, Inc.; Representative Director, Vice Chairman and Executive Officer, Dai-ichi Life Insurance Company, Limited Apr 2020 Director, Vice Chairman and Executive Officer, Head of Innovation Promotion Unit, Dai-ichi Life Holdings, Inc. Apr 2021 Representative Director, Vice Chairman and Executive Officer, Dai-ichi Life Holdings, Inc. Apr 2022 Director, Dai-ichi Life Holdings, Inc. Jun 2022 President and Representative Director, The Dai-ichi Life Economic Research Institute Inc. (current) Mar 2023 Director, the Company (current) Jun 2023 Outside Director, Imperial Hotel, Ltd. (current) Principal concurrent positions: President and Representative Director, The Dai-ichi Life Economic Research Institute Inc.; Outside Director, Imperial Hotel, Ltd.

Apr 2000 Professor, Department of Internal Medicine (Hematology), Dokkyo Medical University Apr 2008 Professor, Department of Internal Medicine (Hematology and Oncology), Dokkyo Medical University Apr 2024 Professor Emerita and Specially Appointed Professor, Dokkyo Medical University (current) Jul 2025 Councilor (part-time), Tokyo Medical University (current) Mar 2026 Director, the Company (scheduled) Principal concurrent positions: Professor Emerita and Specially Appointed Professor, Dokkyo Medical University; Councilor (part-time), Tokyo Medical University Other principal positions: Member (Division II), Science Council of Japan

2003 Joined Roche Group 2005 Head of Marketing and Sales, Roche Diagnostics Austria 2008 General Manager, Roche Sweden 2011 Life Cycle Leader, Sequencing Solutions, Roche 2013 General Manager, Roche Germany 2018 Global Head, Centralized and Point of Care Solutions, Roche Aug 2019 CEO and member of Roche Corporate Executive Committee Jan 2023 CEO, Pharmaceuticals Division, Roche Mar 2023 CEO, Roche Group (current) Mar 2025 Director, the Company (current) Principal concurrent position: CEO, Roche Group Other principal positions: Chairman, International Federation of Pharmaceutical Manufacturers & Associations

Jan 2005 Joined Genentech, Inc. (U.S.) as Product Manager Feb 2010 Sales Manager, Genentech, Inc. Jan 2011 Marketing Director, Genentech, Inc. Sep 2013 Senior Director, Managed Care Dept., Genentech, Inc. Mar 2015 Lifecycle Leader, Actemra, Roche May 2017 Executive Vice President, Rheumatology and Renal, Genentech, Inc. Jan 2018 Executive Vice President, AATE & LGI Sales, Genentech, Inc. May 2019 Global Head, Product Strategy, Pharmaceuticals Division, Roche Mar 2023 CEO, Pharmaceuticals Division, Roche, and member of Roche Corporate Executive Committee (current) Mar 2023 Director, the Company (current) Principal concurrent position: CEO, Pharmaceuticals Division, Roche, and member of Roche Corporate Executive Committee

Sep 1995 Associate, M&A, J.P. Morgan Aug 1999 Partner, Duke Street Capital Nov 2005 Executive Officer, Head of M&A (Corporate), Airbus Group Apr 2012 Head of Business Development and M&A Group, Roche Jul 2024 Head of Corporate Business Development, Roche, and member of Roche Extended Corporate Executive Committee (current) Mar 2025 Director, the Company (current) Principal concurrent position: Head of Corporate Business Development, Roche, and member of Roche Extended Corporate Executive Committee

Apr 1988 Registered as attorney (Second Tokyo Bar Association); joined Anderson Mori & Rabinowitz (now Anderson Mori & Tomotsune) Sep 1993 Registered as attorney in New York State Jan 1997 Partner, Anderson Mori & Tomotsune (current) May 2007 Outside Audit & Supervisory Board Member, Life Net Insurance Co., Ltd. Apr 2010 Part-time Lecturer, Law School, The University of Tokyo Mar 2011 Outside Audit & Supervisory Board Member, Bridgestone Corporation Mar 2016 Outside Director, Bridgestone Corporation (current) May 2016 Outside Audit & Supervisory Board Member, Mercuria Investment Co., Ltd. (now Mercuria Holdings Co., Ltd.) Apr 2019 Visiting Professor, Law School, The University of Tokyo Mar 2020 Audit & Supervisory Board Member, the Company (current) Mar 2025 Outside Director (Audit and Supervisory Committee Member), Mercuria Holdings Co., Ltd. (current) Principal concurrent positions: Partner, Anderson Mori & Tomotsune; Outside Director, Bridgestone Corporation; Outside Director (Audit and Supervisory Committee Member), Mercuria Holdings Co., Ltd.

Apr 1985 Joined Matsuda Masayuki Law & Patent Office (now Mori Hamada & Matsumoto) Apr 2004 Vice President, Second Tokyo Bar Association Apr 2005 Managing Director, Japan Federation of Bar Associations Apr 2013 Joined Tokyo Roppongi Law & Patent Office Jan 2014 Partner, Tokyo Roppongi Law & Patent Office (current) Mar 2014 Outside Audit & Supervisory Board Member, Kao Corporation Mar 2015 Outside Audit & Supervisory Board Member, Asahi Group Holdings, Ltd. Apr 2016 President, Second Tokyo Bar Association; Vice President, Japan Federation of Bar Associations Jun 2021 Outside Audit & Supervisory Board Member, IHI Corporation (current) Mar 2023 Audit & Supervisory Board Member, the Company (current) Jun 2023 Outside Director (Audit and Supervisory Committee Member), SCSK Corporation (current) Principal concurrent positions: Partner, Tokyo Roppongi Law & Patent Office; Outside Audit & Supervisory Board Member, IHI Corporation; Outside Director (Audit and Supervisory Committee Member), SCSK Corporation

May 1985 Joined Aoyama Audit Corporation Sep 2006 Joined Aarata Audit Corporation (now PwC Japan LLC) Jul 2008 Representative Partner, Aarata Audit Corporation Jul 2016 Management Committee Member; Executive Managing Director in charge of Manufacturing, Distribution & Services, PwC Japan LLC Jul 2023 Director, Mami Yunoki CPA Office (current) Mar 2024 Audit & Supervisory Board Member, the Company (current) Jun 2024 Outside Director, Daiwa Securities Group Inc. (current) Jun 2025 Outside Director, ORIX Corporation (current) Principal concurrent positions: Director, Mami Yunoki CPA Office; Outside Director, Daiwa Securities Group Inc.; Outside Director, ORIX Corporation