Apr 1976 Joined the Company Jun 1982 General Manager, Planning Office; Director Jun 1984 Managing Director Jun 1987 Senior Managing Director Apr 1989 General Manager, Corporate Planning Division Jun 1992 Representative Director, President Jun 2014 Representative Director, Chairman (current) Chief Executive Officer (CEO) (current)

Apr 1993 Joined the Company Oct 2017 Deputy General Manager, Business Development Department Apr 2018 Deputy General Manager, Research Administration Department, Research Division Sep 2021 General Manager, Research Administration Department, Research Division Jun 2022 Director; General Manager, Research Division Jun 2026 Representative Director, President (current)

Apr 1985 Joined the Company Oct 2007 Deputy General Manager, Human Resources Department Jun 2010 General Manager, Human Resources Department Jun 2014 Director Jun 2020 Managing Director Jun 2022 Senior Managing Director Oct 2024 Chief Human Resources Officer (CHRO) (current) Jun 2026 Director, Vice President (current)

Apr 1986 Joined the Company Jun 2012 General Manager, Finance and Accounting Department Jun 2016 Executive Officer; General Manager, Finance and Accounting Department Jun 2018 Director Jun 2022 Managing Director Oct 2023 Chief Financial Officer (CFO) (current) Jun 2026 Director, Senior Managing Director (current)

Apr 1987 Joined the Company Jul 2014 Deputy General Manager, Pharmaceutical Planning Department, Pharmaceutical Sales Division Jun 2016 General Manager, Kanetsu Branch, Pharmaceutical Sales Division Jun 2018 General Manager, Pharmaceutical Planning Department, Pharmaceutical Sales Division Oct 2020 Executive Officer; General Manager, Pharmaceutical Planning Department, Pharmaceutical Sales Division Jun 2022 Director; General Manager, Pharmaceutical Sales Division (current) Jun 2026 Managing Director (current)

Apr 1984 Joined the Company Apr 1994 Head, London Office, Development Planning Department, R&D Division Apr 1998 Head, London Office, International Development Department, International Business Division Oct 2003 Deputy General Manager, Business Development Department Apr 2007 General Manager, Business Development Department Jun 2008 Director Jun 2010 General Manager, Corporate Planning Department Jun 2012 General Manager, Development Division Jun 2016 Managing Director Jun 2018 Representative Director, President; Chief Operating Officer (COO) Jun 2022 Director, Senior Advisor (current)

Apr 1989 Joined the Company Oct 2015 Deputy General Manager, Corporate Planning Department Jun 2020 General Manager, Corporate Planning Department Jun 2022 Executive Officer Apr 2026 General Manager, Finance and Accounting Department (current) Jun 2026 Director (current)

Apr 1990 Joined the Company Jun 2016 General Manager, Intellectual Property Department Oct 2025 Deputy General Manager, General Affairs Department Apr 2026 General Manager, General Affairs Department; General Manager, Sustainability Promotion Office (current) Jun 2026 Director (current)

Apr 1972 Joined The Hachijuni Bank, Ltd. Jun 2003 Executive Officer; General Manager, Business Planning Department, the same bank Jun 2007 Managing Director, the same bank Jun 2009 Managing Director; General Manager, Matsumoto Branch Division, the same bank Jun 2011 Retired from the same bank Jun 2011 Representative Director, President, Hachijuni Lease Co., Ltd.; Representative Director, President, Hachijuni Auto Lease Co., Ltd. Jun 2013 Retired from the same company Jun 2013 Part-time Audit & Supervisory Board Member, Hachijuni Securities Co., Ltd. Jun 2014 Director of the Company (current) May 2015 Full-time Audit & Supervisory Board Member, Matsuya Co., Ltd. Jun 2015 Retired as Part-time Audit & Supervisory Board Member, Hachijuni Securities Co., Ltd. Mar 2016 Retired as Full-time Audit & Supervisory Board Member, Matsuya Co., Ltd. Jun 2016 Outside Audit & Supervisory Board Member, Nikkoku Seifun Co., Ltd. Jun 2020 Retired as Outside Audit & Supervisory Board Member, the same company

Apr 1973 Joined Marunouchi Typist School (now Marunouchi Business College) Apr 1996 Principal, Marunouchi Business College Jun 2013 Outside Director, Nagano Bank, Ltd. Jan 2018 President, Shuoukai Educational Corporation (current) Jun 2020 Director of the Company (current) Jun 2023 Outside Audit & Supervisory Board Member, Alpico Holdings Co., Ltd. (current) Dec 2025 Retired as Outside Director, Nagano Bank, Ltd.

Apr 1984 Joined Nagano Prefectural Government Oct 2003 Section Chief, Disability Welfare Division, Social Welfare Department Sep 2010 Planning Officer and Assistant Section Chief, Secretariat Division, General Affairs Department (in charge of Governor's policy secretary) Sep 2014 Section Chief, Secretariat Division, General Affairs Department Apr 2016 Deputy Director, International Affairs, Prefectural Culture Department Sep 2018 Director, Health and Welfare Department Dec 2019 Retired from Nagano Prefectural Government Apr 2020 Director, Community Liaison and Promotion Department, Inochi Sasaeru Suicide Countermeasures Promotion Center (designated corporation of the Minister of Health, Labour and Welfare) Mar 2021 Retired from the same position Apr 2021 Managing Director, Kokusai Shakai Kenzen Ikusei Gakkai Co., Ltd.; Director, Nagano Branch, Japan Association for the United Nations (public interest foundation) Jun 2021 Director, Nagano Nihon University Gakuen Educational Corporation (current) Jan 2022 Auditor, Keiroen Social Welfare Corporation Jun 2022 Director of the Company (current) Jan 2024 Adviser, Kokusai Shakai Kenzen Ikusei Gakkai Co., Ltd. (current) Apr 2025 Managing Director, Nagano Branch, Japan Association for the United Nations (public interest foundation) (current)

Oct 2006 Registered as an attorney (Dai-Ichi Tokyo Bar Association); joined Hirata Law Office Apr 2010 Joined Fukuda Koji Law Office (current) Jun 2013 Auditor, National Association of Libraries (public interest incorporated association) (current) Sep 2020 Audit & Supervisory Board Member, Yuko Co., Ltd. (current) Jun 2026 Director of the Company (current)

Apr 1988 Joined the Company Oct 2011 General Manager, Drug Discovery Research Laboratory No. 1, Drug Discovery Research Department Jun 2012 General Manager, Drug Discovery Research Department, Research Division Jun 2016 Director; General Manager, Research Division Jun 2022 Full-time Audit & Supervisory Board Member (current)

Apr 1989 Joined the Company Apr 2019 General Manager, Development Promotion Department, Development Division Nov 2021 Deputy General Manager, Corporate Planning Department Dec 2022 Adviser, Corporate Planning Department Jun 2024 Full-time Audit & Supervisory Board Member (current)

Apr 1976 Registered as an attorney Apr 1987 Head, Hiromichi Nakagawa Law Office (current) Jun 2011 Audit & Supervisory Board Member of the Company (current)

Aug 1983 Registered as a certified public accountant Jul 1998 Representative Partner, Chuo Audit Corporation (Misuzu Audit Corporation) Jul 2007 Representative Partner, Shin Nihon Audit Corporation (now EY ShinNihon LLC) Jun 2017 Retired as Representative Partner of the same firm Jul 2017 Representative, Michio Iwabuchi CPA Office (current) Jan 2018 Registered as a certified tax accountant May 2018 Outside Director (Audit and Supervisory Committee Member), Takeuchi Mfg. Co., Ltd. (current) Jun 2018 Outside Audit & Supervisory Board Member, R&C Holdings Co., Ltd. (current) Jun 2020 Audit & Supervisory Board Member of the Company (current)