Apr 1994 Joined EDS Japan K.K. Aug 1996 Joined Merrill Lynch Japan Securities Co., Ltd., Investment Banking Division Apr 2005 Director, CFO and General Manager of Administration Division, Perseus Proteomics Inc. Jan 2009 Director, CFO and General Manager of Administration Division, the Company Mar 2011 Representative Director, President, the Company (current) Dec 2016 Representative Director, President, Advanced Immunotherapeutics Inc. Mar 2019 Outside Director, KORTUC Inc.

Apr 1995 Lecturer, Department of Immunology, School of Medicine, Kurume University May 2000 Associate Professor, Department of Immunology, School of Medicine, Kurume University May 2003 Founded the Company; Representative Director Dec 2003 Professor, Advanced Cancer Translational Research Center, Kurume University Jan 2004 Director, the Company (current) Apr 2016 Director, Advanced Cancer Translational Research Center, Kurume University Apr 2022 Special Appointed Professor / Professor Emeritus reporting directly to the President, Kurume University (current) Apr 2022 Advisor, Japanese Society for Cancer Immunology (current)

Apr 1969 Joined McCann-Erickson Hakuhodo Inc. (now McCann Erickson Japan Inc.) Sep 1976 Lecturer, Harvard Business School Dec 1977 Associate Professor, Harvard Business School Apr 1983 Associate Professor, Faculty of Commerce, Hitotsubashi University Apr 1987 Professor, Faculty of Commerce, Hitotsubashi University Apr 1998 Dean, Graduate School of International Corporate Strategy, Hitotsubashi University Apr 2008 Outside Director, Integral Inc. (current) Apr 2010 Professor Emeritus, Hitotsubashi University (current) Jul 2010 Professor, Harvard Business School Jun 2015 Outside Director, the Company (current) Jun 2016 Outside Director, Daiwa Securities Group Inc. Jun 2019 Chairman of the Board of Trustees, International Christian University (current)

Apr 1977 Joined Japan Development Bank (now Development Bank of Japan Inc.) Mar 1992 Visiting Researcher, Brookings Institution (USA) Mar 1993 Senior Researcher, Institute of Capital Investment Research, Japan Development Bank Apr 1997 Director, Toyama Office, Japan Development Bank Jun 1999 Chief Representative, New York Office, Japan Development Bank Jun 2002 Branch Manager, Hokuriku Branch, Development Bank of Japan Inc. Jun 2004 Managing Director, Ikebukuro District Heating and Cooling Co., Ltd. Jun 2016 Senior Managing Director, Ikebukuro District Heating and Cooling Co., Ltd. Jun 2017 Representative Director, Senior Managing Director, Ikebukuro District Heating and Cooling Co., Ltd. Aug 2018 Director, Japan Medical Research Center (general incorporated association) Jun 2019 Outside Corporate Auditor, the Company (current)

Apr 1969 Joined Sankyo Co., Ltd. (now Daiichi Sankyo Company, Limited) Apr 2001 General Manager, Legal Affairs Department, Sankyo Co., Ltd. Feb 2005 Joined PostGenome Institute Co., Ltd. Apr 2005 Joined Sankyo Chemical Industry Co., Ltd. Mar 2006 Corporate Auditor, PostGenome Institute Co., Ltd. Jun 2009 Outside Corporate Auditor, the Company (current)

Apr 1988 Joined Yamaichi Securities Co., Ltd. Apr 1989 Entered Legal Training and Research Institute of the Supreme Court of Japan Apr 1991 Registered with Tokyo Bar Association; joined TMI Associates Sep 1997 Seconded to Eisai Inc. (USA), Legal Department Jun 1998 Registered as attorney in New York State Jun 1998 Seconded to Simmons & Simmons (UK) Apr 1999 Partner, TMI Associates (current) Jun 2015 Outside Corporate Auditor, the Company (current)