Mar 1992: Graduated from Faculty of Medicine, Kyushu University May 1992: Obtained medical license Jun 1992: Joined Department of Urology, Faculty of Medicine, Kyushu University Apr 1998: Postdoctoral Fellow, Mayo Clinic College of Medicine, USA Oct 2002: Assistant Professor, Mayo Clinic College of Medicine Aug 2005: Assistant Professor, Johns Hopkins University School of Medicine, USA Sep 2009: Associate Professor, University of Maryland School of Medicine, USA May 2011: Professor, Department of Immunology, Graduate School of Medicine, Yamaguchi University (current) Mar 2016: Director, the Company Sep 2020: Representative Director, President, the Company (current)

Jun 2006: Joined OncoTherapy Science, Inc. Dec 2014: Representative Director, Leading Valley Inc. Jul 2015: Joined the Company Jan 2018: General Manager, Business Planning Department, Management Administration Division, the Company May 2019: Director, the Company Jun 2019: Head of Business Division and General Manager, Business Planning Department, the Company Jan 2020: General Manager, Business Planning and Research Division, the Company (current)

Apr 1999: Joined Nagano & Morita CPA Jun 2003: Licensed as Certified Public Accountant (Illinois, USA) Feb 2004: Joined Ernst & Young, Global Financial Services Oct 2010: Established Hiroko Nagai CPA Office, Representative Mar 2020: Joined the Company; General Manager, Administration Division (current) Jun 2020: Director, the Company (current)

Jun 2001: President, Sanofi Mama K.K. (now Sanofi K.K.) May 2005: Representative Director, President, Sanofi-Aventis K.K. (now Sanofi K.K.) Jan 2010: President, GlaxoSmithKline K.K. Apr 2017: Chairman, GlaxoSmithKline K.K. May 2019: Outside Director, Bonac Corporation Mar 2020: Outside Director, the Company (current) Sep 2020: Outside Director, Rezolute Inc. (current) Jun 2022: Outside Director, Luca Science Inc. (current) Jun 2022: Outside Director, JCR Pharmaceuticals Co., Ltd. (current) Jun 2023: Director, General Incorporated Association Medical Excellence JAPAN (MEJ) (current)

Apr 1976: Joined Kyowa Hakko Kogyo Co., Ltd. Feb 2003: Established BioWa, Inc., and assumed position of President Mar 2012: Representative Director, President, Kyowa Hakko Kirin Co., Ltd. Mar 2018: Representative Director, Chairman, Kyowa Hakko Kirin Co., Ltd. May 2020: Director, LIVES Capital Inc. Jun 2020: Outside Director, Shimadzu Corporation (current) Mar 2021: Outside Director, Perseus Proteomics Inc. (current) Mar 2024: Outside Director, the Company (current) Jun 2025: Director, LIVES Inc. (current)

Apr 1981: Joined Shinnihon Securities Co., Ltd. (now Mizuho Securities Co., Ltd.) Apr 2011: Executive Officer and Third Block General Manager, Mizuho Securities Co., Ltd. Apr 2012: Deputy General Manager, Marketing Division, Shinko Investment Trust Co., Ltd. Oct 2016: Full-time Audit and Supervisory Board Member, Mizuho Securities Property Management Co., Ltd. Jun 2018: Adviser, Mizuho Securities Property Management Co., Ltd. Jul 2019: Full-time Outside Audit and Supervisory Board Member, the Company (current)

Apr 1991: Joined Sumitomo Bank, Ltd. (now Sumitomo Mitsui Banking Corporation) Apr 1998: Registered as attorney-at-law Sep 2004: Outside Director, Golf Digest Online Inc. Jun 2007: Outside Audit and Supervisory Board Member, United Arrows Ltd. Aug 2008: Established Vasco da Gama Law & Accounting Office; Founding Partner Attorney (current) Jun 2011: Outside Audit and Supervisory Board Member, A.P. Company Co., Ltd. Jun 2011: Outside Audit and Supervisory Board Member, Trenders Inc. (current) Jun 2014: Outside Audit and Supervisory Board Member, iFreak Mobile Inc. Jul 2015: Outside Audit and Supervisory Board Member, the Company (current) Jan 2017: Outside Audit and Supervisory Board Member, Locoguide Inc. Jun 2018: Outside Director, Locoguide Inc. Oct 2021: Outside Director, Kufu Company Holdings Inc. (formerly Kufu Co., Ltd.) (current)

Oct 1996: Joined Asahi Audit Corporation (now Azusa Audit LLC) Apr 1999: Registered as Certified Public Accountant Oct 2001: Joined PwC Tax Corporation Aug 2009: Registered as Certified Public Tax Accountant Sep 2017: Established Yukiyasu Nakada Accounting & Tax Office, Representative (current) Apr 2018: Director, Melk Inc. (now Cocolport Inc.) May 2019: Outside Audit and Supervisory Board Member, the Company (current) May 2022: Outside Audit and Supervisory Board Member, Promat Japan Co., Ltd. Dec 2023: Outside Audit and Supervisory Board Member, Authlete Inc. (current)