Apr 1998 Joined Takeda Pharmaceutical Company Limited Apr 2015 Japan Site Head, Oncology Drug Discovery Research Institute, Takeda Pharmaceutical Company Limited Nov 2017 Representative Director, the Company (current)

Apr 1991 Joined Nippon Long-Term Credit Bank, Ltd. (now SBI Shinsei Bank, Limited) Jul 2004 Deputy Manager, Private Equity Department, the same bank Nov 2012 Director, Shinsei Business Investment Co., Ltd. Apr 2018 Representative Director, Shinsei Capital Partners Co., Ltd. (current) Apr 2019 Outside Director, the Company Apr 2019 Outside Director, AlphaNavi Pharma Inc. (current) Nov 2021 Outside Director, the Company (retired) Nov 2024 Outside Director, the Company (current) Apr 2025 Outside Director, FREST Inc. (current)

Apr 1975 Joined Eisai Co., Ltd. Oct 2004 President, Eisai Europe Ltd. Jun 2005 Executive Officer, Eisai Co., Ltd. Jun 2010 Managing Executive Officer, the same company Jun 2011 Senior Managing Executive Officer, the same company Jun 2012 Representative Executive Senior Managing Officer, the same company Jun 2013 Representative Executive Vice President, the same company Jun 2014 Representative Executive Officer in charge of Healthcare Policy, the same company Dec 2014 Representative Executive Officer in charge of Healthcare Policy and China Business, the same company Jun 2017 Director, the same company Jun 2022 Senior Adviser, the same company Apr 2024 Outside Director, Maruho Co., Ltd. (current) Nov 2025 Outside Director, the Company (current)

Apr 1989 Joined Nihon Keizai Shimbun, Inc. Sep 2002 Joined ANGES, Inc. Jan 2016 Executive Officer, Head of Corporate Strategy Division, ANGES, Inc. Mar 2017 Director, ANGES, Inc. Dec 2018 Representative Director and CEO, Orishiro Genomics Inc. Sep 2022 Director and President, Orishiro Genomics Inc. Jan 2024 Representative Partner, Amirise LLC (current) Nov 2025 Outside Director, the Company (current)

Jan 2005 Joined Arcadia Group, Inc. Nov 2005 Joined ShinNihon Audit Corporation (now EY ShinNihon LLC) Jun 2008 Registered Certified Public Accountant Aug 2013 Joined Megakaryon Corporation Mar 2018 Executive Officer, Megakaryon Corporation Jul 2019 Representative, Ishii Kosuke Accounting Office (current) May 2020 Outside Audit & Supervisory Board Member, Metagen Therapeutics Inc. (current) Sep 2020 Representative Director, BioAid Inc. (current) Mar 2021 Outside Audit & Supervisory Board Member, Mirax Therapeutics Inc. (current) Mar 2021 Outside Director (Audit and Supervisory Committee Member), Lacuoria Drug Discovery Inc. (current) Jun 2021 Outside Audit & Supervisory Board Member, the Company Nov 2022 Outside Director (Audit and Supervisory Committee Member), the Company (current) Mar 2024 Outside Audit & Supervisory Board Member, Fymex Inc. (current) Sep 2024 Outside Audit & Supervisory Board Member, Ciconia Bioventures Inc. (current)

Mar 1983 Joined Takeda Pharmaceutical Company Limited Oct 1998 Manager, Safety Evaluation and Regulatory Affairs Group, Agro Company Oct 2001 Principal Member, Research Strategy Department, Pharmaceutical Research Division Nov 2004 Principal Member, Development Strategy Department, Pharmaceutical Development Division Apr 2009 Senior Director, Takeda Pharmaceutical International Inc. (U.S. assignment) Oct 2012 Principal Member, Corporate Strategy Department Jun 2014 Head of Development Management, Oncology Unit Japan and Asia Apr 2016 Head, Oncology Unit Japan and Asia Oct 2022 Outside Audit & Supervisory Board Member, the Company Nov 2022 Outside Director (Audit and Supervisory Committee Member), the Company (current) Nov 2023 Representative Director, S.A.3 Inc. (current)

Dec 2011 Registered as attorney-at-law, Tokyo Bar Association Jan 2012 Baker & McKenzie Law Office May 2013 Kaneko, Nakamori & Morimoto Patent Law Office Mar 2017 Kottodori Law Office (current) Apr 2017 Part-time Lecturer, Graduate School of Law, Kobe University (current) Apr 2019 Conflict of Interest Advisor, Tokyo University of the Arts (current) Apr 2020 Part-time Lecturer, Ueno Gakuen University Jun 2021 Outside Audit & Supervisory Board Member, the Company Nov 2022 Outside Director (Audit and Supervisory Committee Member), the Company (current) Feb 2023 Visiting Researcher, Max Planck Institute for Innovation and Competition Apr 2024 Part-time Lecturer, Tokyo University of the Arts (current) Jul 2024 Outside Audit & Supervisory Board Member, Allganize Holdings Inc. (current) Apr 2025 Part-time Lecturer, Ueno Gakuen Junior College (current)